Rare Cases of IDH1 Mutations in Spinal Cord Astrocytomas
نویسندگان
چکیده
منابع مشابه
CLINICAL ASPECTS OF SPINAL CORD MENINGIOMAS: ANALYSIS OF FORTY CASES
A retrospective analysis was performed on forty cases of spinal cord meningiomas, operated on at Dr. Shariati Hospital from 1976 to 1990. Age and sex distribution, clinical presentation and tumor location were comparable to those reported by others. In males the tumors were distributed evenly in cervical and dorsal areas and were often anterior to the cord. This finding makes a different s...
متن کاملIDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas.
IDH1 encodes isocitrate dehydrogenase 1, which participates in the citric acid cycle and was recently reported to be mutated in 12% of glioblastomas. We assessed IDH1 mutations in 321 gliomas of various histological types and biological behaviors. A total of 130 IDH1 mutations was detected, and all were located at amino acid residue 132. Of these, 91% were G-->A mutations (Arg-->His). IDH1 muta...
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Epidermoid cyst in the spinal cord is a rare condition. It constitutes of only 0.6-1.1% of all spinal tumors. When they occur, the typical location is in the subdural, extramedullary space of the lumbo-sacral region.We report a forty-two -year-old female who presented with left extremity radicular pain and myelopathy. MRI of the thoracic spine,illustrated a focal fusiform enlargement of the tho...
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Spermatic cord liposarcomas are very rare tumors. Patients usually present with painless growing scrotal swellings which are clinically misdiagnosed as hernia. The correct diagnosis is not common and usually they present as operative or histological surprises. To our knowledge, there are about 186 similar cases reported in the literature. Herein we report three cases of spermatic cord li...
متن کاملIDH1/2 mutations in WHO grade II astrocytomas associated with localization and seizure as the initial symptom
INTRODUCTION Seizures are the most common initial symptom in patients with low-grade glioma and their occurrence strongly depends on the tumor location. The majority of low-grade gliomas reveal mutations in the genes encoding isocitrate-dehydrogenase 1 (IDH1) or 2 (IDH2). These mutations are associated with metabolic changes that are potentially epileptogenic. We investigated the correlation be...
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ژورنال
عنوان ژورنال: Acta Naturae
سال: 2020
ISSN: 2075-8251
DOI: 10.32607/actanaturae.10915